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useful MIF polymorphisms are connected to autoimmune and rheumatic disease susceptibility and severity.

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Fig. four: Diagram of your human MIF gene demonstrating its exonic structure plus the variant microsatellites during the promoter region.

The position of macrophage migration inhibitory element (MIF) in autoimmunity is underscored by information demonstrating that frequent practical polymorphisms in MIF are connected with sickness susceptibility or clinical severity. MIF can control glucocorticoid-mediated immunosuppression and has a well known perform in cell survival signalling.

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MIF regulation of glucocorticoid immunosuppression in addition to a popular perform in cell survival signalling location MIF in a unique posture in the host reaction.

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